EPITRANSCRIPTOMICS:

METHODS, TECHNOLOGIES & INNOVATION

VIRTUAL SYMPOSIUM

JULY 24 - JULY 25, 2023

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recorded sessions

Upcoming Symposium - Spring/Summer of 2025

Hosted by: The Center for Genomic Information

Encoded by RNA Nucleotide Modifications

supported by:

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This two-day

virtual symposium will

focus on recent advances in Epitranscriptomics research, with a particular emphasis on new and emerging technologies for studying modifications in tRNA, rRNA, and mRNA.


Speakers span diverse areas of RNA modifications research and include experts from both industry and academia.

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dates & times

monday, july 24, 2023 - 10:30 AM - 4:15 PM EST

tuesday, july 25, 2023 - 10:30 AM - 5:15 PM EST

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SYMPOSIUM AGENDA




10:15AM-10:30AM - WELCOME REMARKS

DR. SAMIE JAFFREY - WEILL CORNELL MEDICINE

DR. KATE MEYER - DUKE UNIVERSITY

MONDAY, JULY 24, 2023. DAY 1 - AGENDA

DAY 1: SESSION 1

TOPIC OF SESSION: Emerging technologies for mapping m6A

SPEAKERS: (20min talks, 5mins Q&A) Moderator: Dr. Samie Jaffrey - Weill Cornell Medicine

10:30am -10:50am

Dr. Kate Meyer, Duke University - "Transcriptome-wide profiling of m6A in single cells"

10:55am - 11:15am

Dr. Schraga Schwartz, Weizmann Institute - "Deciphering the code governing mRNA methylation"


11:20am - 11:30am BREAK


11:30am - 11:50pm

Dr. Chengqi Yi, Peking University - "Absolute quantification of RNA m6A methylome at the single-base resolution"

11:55pm - 12:15pm

Dr. Weixin Tang: University of Chicago - "Transcriptome-wide profiling & quantification of N6-methyladenosine by enzyme-assisted adenosine deamination"

DAY 1: PANEL 1

PANEL TOPIC: How to choose the right approach for mapping m6A

PANELISTS (session is for all speakers and attendees)

12:20pm - 1:00pm

  • Moderator: Dr. Samie Jaffrey - Weill Cornell Medicine
  • Dr. Kate Meyer - Duke University
  • Dr. Schraga Schwartz – Weizmann Institute
  • Dr. Chengqi Yi - Peking University
  • Dr. Weixin Tang - University of Chicago



1:00PM - 1:30PM - LUNCH

DAY 1: SESSION 2

TOPIC OF SESSION: New instrumentation for detecting and quantifying RNA modifications

SPEAKERS: (20min talks, 5mins Q&A) Moderator: Dr. Kate Meyer - Duke University

1:30pm - 1:50pm

Dr. Jonathan Göke - Genome Institute of Singapore: "Identification of m6A RNA modifications at single molecule resolution using nanopore direct RNA-Seq data"

1:55pm - 2:15pm

Dr. Shuo Huang - Nanjing University - "Identification of epigenetically modified RNA nucleotides using a reactive nanopore sensor"

2:20pm - 2:40pm

Dr. Eva Maria Novoa: Centre for Genomic Regulation: “Decoding the epitranscriptome at single nucleotide & single molecule resolution using nanopore sequencing"

2:45pm - 3:05pm

Dr. Logan Mulroney - Instituto Italiano Di Tecnologia - "Investigating RNA modifications with Nanocompore"


3:10pm - 3:20pm BREAK


DAY 1: PANEL 2

PANEL TOPIC: How to select and use ONT and other technologies for mapping modifications

PANELISTS (session is for all speakers and attendees)

3:20pm - 4:15pm

  • Moderator: Dr. Kate Meyer - Duke University
  • Dr. Jonas Korlach - PacBio (10 min presentation)
  • Dr. Logan Mulroney - Instituto Italiano Di Tecnologia
  • Dr. Eva Maria Novoa - Centre for Genomic Regulation
  • Dr. Jonathan Göke - Genome Institute of Singapore
  • Dr. Shuo Huang - Nanjing University


END OF DAY 1


TUESDAY, JULY 25, 2023. DAY 2 - AGENDA

DAY 2: SESSION 1

TOPIC OF SESSION: Methods for quantifying and mapping modified nucleotides in tRNA

SPEAKERS: (20min talks, 5mins Q&A) Moderator: Dr. Scott Blanchard – St. Jude Research Hospital

10:30am - 10:50am

Dr. Richard Gregory - Harvard University: "Deciphering m7G and m3C methylomes and their role in tRNA biology"

10:55am - 11:15am

Dr. Tao Pan - University of Chicago: "Functional Genomics and Epitranscriptomics of tRNA from Cells to Microbiomes"

11:20am - 11:40am

Dr. Shenglong Zhang - New York Institute of Technology - "Empowering Mass Spectrometry: Large-Scale De Novo Direct & Unbiased Sequencing of RNA Modifications”

11:45am - 12:05pm

Dr. Peter Dedon - M.I.T. - "New analytical tools for functional epitranscriptomics"


12:10pm - 12:20pm BREAK



DAY 2: PANEL 1

PANEL TOPIC: Methods for quantifying and mapping tRNA modifications

PANELISTS (session is for all speakers and attendees)

12:20pm - 1:00pm

  • Moderator: Dr. Scott Blanchard – St. Jude Research Hospital
  • Dr. Qi Chen - University of Utah (10 min Presentation)
  • Dr. Richard Gregory - Harvard University
  • Dr. Tao Pan - University of Chicago
  • Dr. Shenglong Zhang - New York Institute of Technology
  • Dr. Peter Dedon - M.I.T.



1:00PM - 1:30PM - LUNCH

DAY 2: SESSION 2

TOPIC OF SESSION: Methods for quantifying and mapping rRNA modifications

SPEAKERS: (20min talks, 5mins Q&A) Moderator: Dr. Davide Ruggero - University of California: San Francisco

1:30pm - 1:50pm

Dr. Yuri Motorin – University of Lorraine - "Challenges and solutions in epitranscriptomic analysis by deep sequencing"

1:55pm - 2:15pm

Dr. Davide Ruggero - University of California: San Francisco - "rRNA modifications in health and disease"

2:20pm - 2:40pm

Dr. Sarath Janga - Luddy School of Informatics, Indiana University (IUPUI) - “Single molecule mapping of RNA modifications & structures using direct RNA-sequencing”

2:45pm - 3:05pm

Dr. Cynthia Burrows - University of Utah - “Nanopore sequencing for 17 modifications in ribosomes under stress is aided by dwell-time analysis”


3:10pm - 3:20pm BREAK


DAY 2: PANEL 2

PANEL TOPIC: What are the major challenges for rRNA modification detection?

PANELISTS (session is for all speakers and attendees)

3:20pm - 4:00pm

  • Moderator - Dr. Davide Ruggero - University of California: San Francisco
  • Dr. Yuri Motorin – University of Lorraine
  • Dr. Sarath Janga - Indiana Univ. School of Medicine
  • Dr. Cynthia Burrows - University of Utah


DAY 2: SESSION 3

TOPIC OF SESSION: Emerging methods for installing and manipulating RNA modifications

SPEAKERS: (20min talks, 5mins Q&A) Moderator: Dr. Shenglong Zhang - New York Institute of Technology

4:00pm - 4:20pm

Dr. Prashant Mali, UC San Diego Health Sciences - "Programmable Modulation of RNA editing: New Approaches, New Challenges"

4:25pm - 4:45pm

Dr. Yi-Tao Yu, University of Rochester Medical Center - "Modulating gene expression by targeted RNA pseudouridylation"

4:50pm - 5:10pm

Dr. Josh Huang, Duke University - "Programmable RNA sensing for cell monitoring and control"


END OF SYMPOSIUM